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<h4>Kok Hao CHEN, Ph.D.</h4>
<p>Principal Scientist II</p></a>
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<p>Senior Scientist I</p>
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<p>Senior Scientist I</p>
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<p>Lead Research Officer II</p>
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<p>Scientist</p>
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<h4>Jiao, CAO, Ph.D.</h4>
<p>Scientist</p>
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<h1 class="text-white">Former Members</h1>
<p>Vipul Singhal, 2018-2024. Integrated Biosciences</p>
<p>Nigel Chou Shiji, 2017-2023. GIS Fellow at Genome Institute of Singapore</p>
<p>Lurong Wang, 2022-2024. Research Officer at Genome Institute of Singapore</p>
<p>Jiamin Toh, 2019-2024. Research Officer at Genome Institute of Singapore</p>
<p>Norbert Ha, 2019-2024. Biomedical Scientist at Delta Electronics</p>
<p>Jack Petts-Lewis, 2021-2023. Graduate Student at University of Warwick</p>
<p>Lingfan Jiang, 2019-2023. Research Scientist at KLA</p>
<p>Jazlynn Tan, 2022. University of Toronto</p>
<p>Jeeranan Boonruangkan, 2018-2022. Biofourmis</p>
<p>Jie Lin Jolene Goh, 2016-2022. Veranome Biosystems</p>
<p>Mike Jin-An Huang, 2018-2021. 1910 Genetics</p>
<p>Paul Cheng, 2018-2021. Veranome Biosystems</p>
<p>Kaviya Selva Raju, 2018-2020. Research associate at Applied Materials</p>
<p>Siyi Chen, 2018. Senior scientist at Maiden Therapeutics</p>
<p>Christabelle Goh, 2018. Scientist II at Applied Materials</p>
<p>Ziqing, Winston Zhao, 2018-2019. Assistant professor at National University of Singapore</p>
<p>Teck Por Lim, 2018-2019.</p>
<p>Mei Lun Chow, 2018. Project officer at Nanyang Technological University</p>
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<h1 class="text-white">Publications</h1>
<p>Zhou, X.*, Seow, W. Y.*, Ha, N., Cheng, T. H., Jiang, L. F., Boonruangkan, J., Goh, J. J. L., Prabhakar, S., Chou, N.#, Chen, K. H.#, Highly sensitive spatial transcriptomics using FISHnCHIPs of multiple co-expressed genes, Nature Communications, (2024) DOI: 10.1038/s41467-024-46669-y.</p>
<p>Singhal, V.*, Chou, N.*, Lee, J., Yue, Y., Liu, J., Chock, W. K., Lin, Li, Chang, Y., Teo, E., Lee, H. K., Chen, K. H.#, Prabhakar, S.#, BANKSY unifies cell typing and tissue domain segmentation for scalable spatial omics data analysis, Nature Genetics, (2024) DOI: 10.1038/s41588-024-01664-3.</p>
<p>Goh, J. J. L.*, Chou, N.*, Seow, W. Y., Ha, N., Cheng, C. P. P., Chang, Y., Zhao, Z. W., Chen, K. H. Highly specific multiplexed RNA imaging in tissues with split-FISH. Nature Methods, (2020) https://doi.org/10.1038/s41592-020-0858-0.</p>
<p>Li, H., Courtois, E. T., Sengupta, D., Tan, Y., Chen, K. H., Goh, J. J. L., et al. Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors. Nature Genetics (49), 708–718 (2017).</p>
<p>Moffitt, J. R.*, Hao, J.*, Wang, G.*, Chen, K. H., Babcock, H. P. & Zhuang, X. High-throughput single-cell gene-expression profiling with multiplexed error-robust fluorescence in situ hybridization. P.N.A.S. 113 (39), 11046-11051 (2016).</p>
<p>Chen, K. H.*, Boettiger, A. N.*, Moffitt, J. R.*, Wang, S. & Zhuang, X. Spatially resolved, highly multiplexed RNA profiling in single cells. Science 348, aaa6090 (2015).</p>
<p>Cha, T. G., Baker, B.A., Salgado J., Bates C.J., Chen K.H., Chang A.C., Han J.C., Strano M.S., & Choi J.H. Understanding oligonucleotide-templated nanocrystals: Growth mechanisms and surface properties. ACS Nano 6, 8136–8143 (2012).</p>
<p>Bates, M., Dempsey, G. T., Chen, K. H. & Zhuang, X. Multicolor super-resolution fluorescence imaging via multi-parameter fluorophore detection. ChemPhysChem 13, 99–107 (2012).</p>
<p>Chen, K. H., Hobley, J., Foo, Y. L. & Su, X. Wide-field single metal nanoparticle spectroscopy for high throughput localized surface plasmon resonance sensing. Lab Chip 11, 1895–1901 (2011).</p>
<p>Dempsey, G. T.*, Vaughan, J. C.*, Chen, K. H.*, Bates, M. & Zhuang, X. Evaluation of fluorophores for optimal performance in localization-based super-resolution imaging. Nature Methods 8, 1027–1036 (2011).</p>
<p>Ishitsuka, Y., Okumus, B., Arslan, S., Chen, K. H. & Ha, T. Temperature-independent porous nanocontainers for single-molecule fluorescence studies. Anal. Chem. 82, 9694–9701 (2010).</p>
<p>Mateo-Alonso, A., Ehli, C., Chen, K. H., Guldi, D. M. & Prato, M. Dispersion of single-walled carbon nanotubes with an extended diazapentacene derivative. J. Phys. Chem. A 111, 12669–12673 (2007).</p>
<p>Choi, J. H., Chen, K. H. & Strano, M. S. Aptamer-capped nanocrystal quantum dots: A new method for label-free protein detection. J. Am. Chem. Soc. 128, 15584–15585 (2006).</p>
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<p>We’re located on level 5 of the Genome Institute of Singapore, at the Biopolis research campus in the One-North area.</p>
<p>Our mailing address is: Genome Institute of Singapore (GIS), 60 Biopolis Street Level 5, Genome Building, Singapore 138672</p>
<p>Positions available.
Email:chenkh(at) gis.a-star.edu.sg</p>
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