diff --git a/Formula/libsbml.rb b/Formula/libsbml.rb
new file mode 100644
index 000000000..9fa08e535
--- /dev/null
+++ b/Formula/libsbml.rb
@@ -0,0 +1,71 @@
+class Libsbml < Formula
+  desc "Library for handling SBML (Systems Biology Markup Language)"
+  homepage "https://sbml.org/software/libsbml"
+  url "https://github.com/sbmlteam/libsbml/archive/refs/tags/v5.20.2.tar.gz"
+  sha256 "a196cab964b0b41164d4118ef20523696510bbfd264a029df00091305a1af540"
+  license "LGPL-2.1-only"
+
+  depends_on "check" => :build
+  depends_on "cmake" => :build
+  depends_on "pkg-config" => :build
+
+  uses_from_macos "bzip2"
+  uses_from_macos "libxml2"
+
+  def install
+    # avoid an error "invalid conversion from ‘const xmlError*’"
+    ENV.append_to_cflags "-fpermissive" if OS.linux?
+    args = %w[
+      -DWITH_SWIG=OFF
+      -DWITH_ZLIB=OFF
+      -DWITH_BZIP2=ON
+      -DENABLE_COMP=ON
+      -DENABLE_FBC=ON
+      -DENABLE_GROUPS=ON
+      -DENABLE_L3V2EXTENDEDMATH=ON
+      -DENABLE_LAYOUT=ON
+      -DENABLE_MULTI=ON
+      -DENABLE_QUAL=ON
+      -DENABLE_RENDER=ON
+    ]
+    args << "-DLIBSBML_DEPENDENCY_DIR=#{HOMEBREW_PREFIX}"
+    system "cmake", "-S", ".", "-B", "build", *args, *std_cmake_args
+    system "cmake", "--build", "build"
+    system "cmake", "--install", "build"
+  end
+
+  test do
+    (testpath/"test.cpp").write <<~EOS
+      #include <sbml/SBMLTypes.h>
+      #include <sbml/packages/fbc/common/FbcExtensionTypes.h>
+      #include <sbml/packages/groups/common/GroupsExtensionTypes.h>
+
+      LIBSBML_CPP_NAMESPACE_USE
+
+      int main(int argc,char** argv)
+      {
+        SBMLNamespaces sbmlns(3,2);
+
+        sbmlns.addPkgNamespace("fbc",1);
+        sbmlns.addPkgNamespace("groups",1);
+
+        // create the document
+
+        SBMLDocument *document = new SBMLDocument(&sbmlns);
+        document->setPackageRequired("fbc", false);
+        document->setPackageRequired("groups", false);
+
+        // create the model
+        Model* model = document->createModel();
+
+        // basic test
+        model->setId("Homebrew_SBMLtest");
+        std::cout << model->getId() << std::endl;
+
+        return 0;
+      }
+    EOS
+    system ENV.cxx, "-std=c++17", "-L#{lib}", "-I#{include}", "test.cpp", "-o", "test", "-lsbml"
+    assert_equal "Homebrew_SBMLtest", shell_output("./test").strip
+  end
+end