diff --git a/.github/component_owners.yml b/.github/component_owners.yml
index 5cbb6aa402..81a9647788 100644
--- a/.github/component_owners.yml
+++ b/.github/component_owners.yml
@@ -61,6 +61,9 @@ components:
   instrumentation/opentelemetry-instrumentation-psycopg:
     - federicobond
 
+  instrumentation/opentelemetry-instrumentation-pymssql:
+    - guillaumep
+
   instrumentation/opentelemetry-instrumentation-aiokafka:
     - dimastbk
 
diff --git a/.github/workflows/core_contrib_test_0.yml b/.github/workflows/core_contrib_test_0.yml
index 6a70ce8380..a8336e093f 100644
--- a/.github/workflows/core_contrib_test_0.yml
+++ b/.github/workflows/core_contrib_test_0.yml
@@ -1273,6 +1273,28 @@ jobs:
       - name: Run tests
         run: tox -e py38-test-instrumentation-pymysql -- -ra
 
+  py38-test-instrumentation-pymssql:
+    name: instrumentation-pymssql 
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout contrib repo @ SHA - ${{ env.CONTRIB_REPO_SHA }}
+        uses: actions/checkout@v4
+        with:
+          repository: open-telemetry/opentelemetry-python-contrib
+          ref: ${{ env.CONTRIB_REPO_SHA }}
+
+      - name: Set up Python 3.8
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.8"
+          architecture: "x64"
+
+      - name: Install tox
+        run: pip install tox-uv
+
+      - name: Run tests
+        run: tox -e py38-test-instrumentation-pymssql -- -ra
+
   py38-test-instrumentation-pyramid:
     name: instrumentation-pyramid 
     runs-on: ubuntu-latest
diff --git a/.github/workflows/lint_0.yml b/.github/workflows/lint_0.yml
index 34db823570..cc7cfd536f 100644
--- a/.github/workflows/lint_0.yml
+++ b/.github/workflows/lint_0.yml
@@ -664,6 +664,24 @@ jobs:
       - name: Run tests
         run: tox -e lint-instrumentation-pymysql
 
+  lint-instrumentation-pymssql:
+    name: instrumentation-pymssql
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python 3.13
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.13"
+
+      - name: Install tox
+        run: pip install tox-uv
+
+      - name: Run tests
+        run: tox -e lint-instrumentation-pymssql
+
   lint-instrumentation-pyramid:
     name: instrumentation-pyramid
     runs-on: ubuntu-latest
diff --git a/.github/workflows/test_1.yml b/.github/workflows/test_1.yml
index b27fe28466..f2686cfe91 100644
--- a/.github/workflows/test_1.yml
+++ b/.github/workflows/test_1.yml
@@ -2338,6 +2338,114 @@ jobs:
       - name: Run tests
         run: tox -e pypy3-test-instrumentation-pymysql -- -ra
 
+  py38-test-instrumentation-pymssql_ubuntu-latest:
+    name: instrumentation-pymssql 3.8 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python 3.8
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.8"
+
+      - name: Install tox
+        run: pip install tox-uv
+
+      - name: Run tests
+        run: tox -e py38-test-instrumentation-pymssql -- -ra
+
+  py39-test-instrumentation-pymssql_ubuntu-latest:
+    name: instrumentation-pymssql 3.9 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python 3.9
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.9"
+
+      - name: Install tox
+        run: pip install tox-uv
+
+      - name: Run tests
+        run: tox -e py39-test-instrumentation-pymssql -- -ra
+
+  py310-test-instrumentation-pymssql_ubuntu-latest:
+    name: instrumentation-pymssql 3.10 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python 3.10
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.10"
+
+      - name: Install tox
+        run: pip install tox-uv
+
+      - name: Run tests
+        run: tox -e py310-test-instrumentation-pymssql -- -ra
+
+  py311-test-instrumentation-pymssql_ubuntu-latest:
+    name: instrumentation-pymssql 3.11 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python 3.11
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.11"
+
+      - name: Install tox
+        run: pip install tox-uv
+
+      - name: Run tests
+        run: tox -e py311-test-instrumentation-pymssql -- -ra
+
+  py312-test-instrumentation-pymssql_ubuntu-latest:
+    name: instrumentation-pymssql 3.12 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python 3.12
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.12"
+
+      - name: Install tox
+        run: pip install tox-uv
+
+      - name: Run tests
+        run: tox -e py312-test-instrumentation-pymssql -- -ra
+
+  py313-test-instrumentation-pymssql_ubuntu-latest:
+    name: instrumentation-pymssql 3.13 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python 3.13
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.13"
+
+      - name: Install tox
+        run: pip install tox-uv
+
+      - name: Run tests
+        run: tox -e py313-test-instrumentation-pymssql -- -ra
+
   py38-test-instrumentation-pyramid_ubuntu-latest:
     name: instrumentation-pyramid 3.8 Ubuntu
     runs-on: ubuntu-latest
@@ -4407,111 +4515,3 @@ jobs:
 
       - name: Run tests
         run: tox -e py311-test-instrumentation-httpx-1 -- -ra
-
-  py312-test-instrumentation-httpx-0_ubuntu-latest:
-    name: instrumentation-httpx-0 3.12 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python 3.12
-        uses: actions/setup-python@v5
-        with:
-          python-version: "3.12"
-
-      - name: Install tox
-        run: pip install tox-uv
-
-      - name: Run tests
-        run: tox -e py312-test-instrumentation-httpx-0 -- -ra
-
-  py312-test-instrumentation-httpx-1_ubuntu-latest:
-    name: instrumentation-httpx-1 3.12 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python 3.12
-        uses: actions/setup-python@v5
-        with:
-          python-version: "3.12"
-
-      - name: Install tox
-        run: pip install tox-uv
-
-      - name: Run tests
-        run: tox -e py312-test-instrumentation-httpx-1 -- -ra
-
-  py313-test-instrumentation-httpx-1_ubuntu-latest:
-    name: instrumentation-httpx-1 3.13 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python 3.13
-        uses: actions/setup-python@v5
-        with:
-          python-version: "3.13"
-
-      - name: Install tox
-        run: pip install tox-uv
-
-      - name: Run tests
-        run: tox -e py313-test-instrumentation-httpx-1 -- -ra
-
-  pypy3-test-instrumentation-httpx-0_ubuntu-latest:
-    name: instrumentation-httpx-0 pypy-3.8 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python pypy-3.8
-        uses: actions/setup-python@v5
-        with:
-          python-version: "pypy-3.8"
-
-      - name: Install tox
-        run: pip install tox-uv
-
-      - name: Run tests
-        run: tox -e pypy3-test-instrumentation-httpx-0 -- -ra
-
-  pypy3-test-instrumentation-httpx-1_ubuntu-latest:
-    name: instrumentation-httpx-1 pypy-3.8 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python pypy-3.8
-        uses: actions/setup-python@v5
-        with:
-          python-version: "pypy-3.8"
-
-      - name: Install tox
-        run: pip install tox-uv
-
-      - name: Run tests
-        run: tox -e pypy3-test-instrumentation-httpx-1 -- -ra
-
-  py38-test-util-http_ubuntu-latest:
-    name: util-http 3.8 Ubuntu
-    runs-on: ubuntu-latest
-    steps:
-      - name: Checkout repo @ SHA - ${{ github.sha }}
-        uses: actions/checkout@v4
-
-      - name: Set up Python 3.8
-        uses: actions/setup-python@v5
-        with:
-          python-version: "3.8"
-
-      - name: Install tox
-        run: pip install tox-uv
-
-      - name: Run tests
-        run: tox -e py38-test-util-http -- -ra
diff --git a/.github/workflows/test_2.yml b/.github/workflows/test_2.yml
index d9b622c5c3..96ebfba82a 100644
--- a/.github/workflows/test_2.yml
+++ b/.github/workflows/test_2.yml
@@ -16,6 +16,114 @@ env:
 
 jobs:
 
+  py312-test-instrumentation-httpx-0_ubuntu-latest:
+    name: instrumentation-httpx-0 3.12 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python 3.12
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.12"
+
+      - name: Install tox
+        run: pip install tox-uv
+
+      - name: Run tests
+        run: tox -e py312-test-instrumentation-httpx-0 -- -ra
+
+  py312-test-instrumentation-httpx-1_ubuntu-latest:
+    name: instrumentation-httpx-1 3.12 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python 3.12
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.12"
+
+      - name: Install tox
+        run: pip install tox-uv
+
+      - name: Run tests
+        run: tox -e py312-test-instrumentation-httpx-1 -- -ra
+
+  py313-test-instrumentation-httpx-1_ubuntu-latest:
+    name: instrumentation-httpx-1 3.13 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python 3.13
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.13"
+
+      - name: Install tox
+        run: pip install tox-uv
+
+      - name: Run tests
+        run: tox -e py313-test-instrumentation-httpx-1 -- -ra
+
+  pypy3-test-instrumentation-httpx-0_ubuntu-latest:
+    name: instrumentation-httpx-0 pypy-3.8 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python pypy-3.8
+        uses: actions/setup-python@v5
+        with:
+          python-version: "pypy-3.8"
+
+      - name: Install tox
+        run: pip install tox-uv
+
+      - name: Run tests
+        run: tox -e pypy3-test-instrumentation-httpx-0 -- -ra
+
+  pypy3-test-instrumentation-httpx-1_ubuntu-latest:
+    name: instrumentation-httpx-1 pypy-3.8 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python pypy-3.8
+        uses: actions/setup-python@v5
+        with:
+          python-version: "pypy-3.8"
+
+      - name: Install tox
+        run: pip install tox-uv
+
+      - name: Run tests
+        run: tox -e pypy3-test-instrumentation-httpx-1 -- -ra
+
+  py38-test-util-http_ubuntu-latest:
+    name: util-http 3.8 Ubuntu
+    runs-on: ubuntu-latest
+    steps:
+      - name: Checkout repo @ SHA - ${{ github.sha }}
+        uses: actions/checkout@v4
+
+      - name: Set up Python 3.8
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.8"
+
+      - name: Install tox
+        run: pip install tox-uv
+
+      - name: Run tests
+        run: tox -e py38-test-util-http -- -ra
+
   py39-test-util-http_ubuntu-latest:
     name: util-http 3.9 Ubuntu
     runs-on: ubuntu-latest
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 80da336aee..8f78a8d50f 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -47,6 +47,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
   ([#3200](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3200))
 - `opentelemetry-opentelemetry-botocore` Add basic support for GenAI attributes for AWS Bedrock ConverseStream API
   ([#3204](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3204))
+- `opentelemetry-instrumentation-pymssql` Add pymssql instrumentation
+  ([#394](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/394))
 
 ### Fixed
 
@@ -69,7 +71,6 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - `opentelemetry-instrumentation-dbapi` including sqlcomment in `db.statement` span attribute value is now opt-in
   ([#3115](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3115))
 
-
 ### Breaking changes
 
 - `opentelemetry-instrumentation-dbapi` including sqlcomment in `db.statement` span attribute value is now opt-in
@@ -77,7 +78,6 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - `opentelemetry-instrumentation-psycopg2`, `opentelemetry-instrumentation-psycopg`, `opentelemetry-instrumentation-mysqlclient`, `opentelemetry-instrumentation-pymysql`: including sqlcomment in `db.statement` span attribute value is now opt-in
   ([#3121](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3121))
 
-
 ## Version 1.29.0/0.50b0 (2024-12-11)
 
 ### Added
diff --git a/docs-requirements.txt b/docs-requirements.txt
index d547e806a3..0e36426fe3 100644
--- a/docs-requirements.txt
+++ b/docs-requirements.txt
@@ -35,6 +35,7 @@ psycopg~=3.1.17
 pika>=0.12.0
 pymongo~=4.6.3
 PyMySQL~=1.1.1
+pymssql~=2.3.2
 pyramid>=1.7
 redis>=2.6
 remoulade>=0.50
diff --git a/docs/instrumentation/pymssql/pymssql.rst b/docs/instrumentation/pymssql/pymssql.rst
new file mode 100644
index 0000000000..0b1b589cb9
--- /dev/null
+++ b/docs/instrumentation/pymssql/pymssql.rst
@@ -0,0 +1,7 @@
+OpenTelemetry pymssql Instrumentation
+=====================================
+
+.. automodule:: opentelemetry.instrumentation.pymssql
+    :members:
+    :undoc-members:
+    :show-inheritance:
diff --git a/instrumentation/README.md b/instrumentation/README.md
index a229951b4b..dcfcf46edd 100644
--- a/instrumentation/README.md
+++ b/instrumentation/README.md
@@ -35,6 +35,7 @@
 | [opentelemetry-instrumentation-psycopg2](./opentelemetry-instrumentation-psycopg2) | psycopg2 >= 2.7.3.1,psycopg2-binary >= 2.7.3.1 | No | experimental
 | [opentelemetry-instrumentation-pymemcache](./opentelemetry-instrumentation-pymemcache) | pymemcache >= 1.3.5, < 5 | No | experimental
 | [opentelemetry-instrumentation-pymongo](./opentelemetry-instrumentation-pymongo) | pymongo >= 3.1, < 5.0 | No | experimental
+| [opentelemetry-instrumentation-pymssql](./opentelemetry-instrumentation-pymssql) | pymssql >= 2.1.5, < 3 | No | experimental
 | [opentelemetry-instrumentation-pymysql](./opentelemetry-instrumentation-pymysql) | PyMySQL < 2 | No | experimental
 | [opentelemetry-instrumentation-pyramid](./opentelemetry-instrumentation-pyramid) | pyramid >= 1.7 | Yes | experimental
 | [opentelemetry-instrumentation-redis](./opentelemetry-instrumentation-redis) | redis >= 2.6 | No | experimental
diff --git a/instrumentation/opentelemetry-instrumentation-dbapi/src/opentelemetry/instrumentation/dbapi/__init__.py b/instrumentation/opentelemetry-instrumentation-dbapi/src/opentelemetry/instrumentation/dbapi/__init__.py
index 27aafc7308..c7b1dee3b2 100644
--- a/instrumentation/opentelemetry-instrumentation-dbapi/src/opentelemetry/instrumentation/dbapi/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-dbapi/src/opentelemetry/instrumentation/dbapi/__init__.py
@@ -204,10 +204,12 @@ def instrument_connection(
     commenter_options: dict[str, Any] | None = None,
     connect_module: Callable[..., Any] | None = None,
     enable_attribute_commenter: bool = False,
+    db_api_integration_factory: type[DatabaseApiIntegration] | None = None,
 ) -> TracedConnectionProxy[ConnectionT]:
     """Enable instrumentation in a database connection.
 
     Args:
+        name: The instrumentation module name.
         connection: The connection to instrument.
         database_system: An identifier for the database management system (DBMS)
             product being used.
@@ -220,6 +222,10 @@ def instrument_connection(
         commenter_options: Configurations for tags to be appended at the sql query.
         connect_module: Module name where connect method is available.
         enable_attribute_commenter: Flag to enable/disable sqlcomment inclusion in `db.statement` span attribute. Only available if enable_commenter=True.
+        db_api_integration_factory: A class or factory function to use as a
+            replacement for :class:`DatabaseApiIntegration`. Can be used to
+            obtain connection attributes from the connect method instead of
+            from the connection itself (as done by the pymssql intrumentor).
 
     Returns:
         An instrumented connection.
@@ -228,7 +234,11 @@ def instrument_connection(
         _logger.warning("Connection already instrumented")
         return connection
 
-    db_integration = DatabaseApiIntegration(
+    db_api_integration_factory = (
+        db_api_integration_factory or DatabaseApiIntegration
+    )
+
+    db_integration = db_api_integration_factory(
         name,
         database_system,
         connection_attributes=connection_attributes,
diff --git a/instrumentation/opentelemetry-instrumentation-dbapi/tests/test_dbapi_integration.py b/instrumentation/opentelemetry-instrumentation-dbapi/tests/test_dbapi_integration.py
index 3d531fb791..97d53f33ec 100644
--- a/instrumentation/opentelemetry-instrumentation-dbapi/tests/test_dbapi_integration.py
+++ b/instrumentation/opentelemetry-instrumentation-dbapi/tests/test_dbapi_integration.py
@@ -46,7 +46,9 @@ def test_span_succeeded(self):
             "user": "user",
         }
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname", "testcomponent", connection_attributes
+            "instrumenting_module_test_name",
+            "testcomponent",
+            connection_attributes,
         )
         mock_connection = db_integration.wrapped_connection(
             mock_connect, {}, connection_props
@@ -78,7 +80,7 @@ def test_span_succeeded(self):
 
     def test_span_name(self):
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname", "testcomponent", {}
+            "instrumenting_module_test_name", "testcomponent", {}
         )
         mock_connection = db_integration.wrapped_connection(
             mock_connect, {}, {}
@@ -117,7 +119,7 @@ def test_span_succeeded_with_capture_of_statement_parameters(self):
             "user": "user",
         }
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "testcomponent",
             connection_attributes,
             capture_parameters=True,
@@ -169,7 +171,9 @@ def test_span_not_recording(self):
         mock_span = mock.Mock()
         mock_span.is_recording.return_value = False
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname", "testcomponent", connection_attributes
+            "instrumenting_module_test_name",
+            "testcomponent",
+            connection_attributes,
         )
         mock_connection = db_integration.wrapped_connection(
             mock_connect, {}, connection_props
@@ -183,7 +187,7 @@ def test_span_not_recording(self):
 
     def test_span_failed(self):
         db_integration = dbapi.DatabaseApiIntegration(
-            self.tracer, "testcomponent"
+            "instrumenting_module_test_name", "testcomponent"
         )
         mock_connection = db_integration.wrapped_connection(
             mock_connect, {}, {}
@@ -207,7 +211,9 @@ def test_custom_tracer_provider_dbapi(self):
         tracer_provider, exporter = result
 
         db_integration = dbapi.DatabaseApiIntegration(
-            self.tracer, "testcomponent", tracer_provider=tracer_provider
+            "instrumenting_module_test_name",
+            "testcomponent",
+            tracer_provider=tracer_provider,
         )
         mock_connection = db_integration.wrapped_connection(
             mock_connect, {}, {}
@@ -224,7 +230,7 @@ def test_custom_tracer_provider_dbapi(self):
 
     def test_no_op_tracer_provider(self):
         db_integration = dbapi.DatabaseApiIntegration(
-            self.tracer,
+            "instrumenting_module_test_name",
             "testcomponent",
             tracer_provider=trace_api.NoOpTracerProvider(),
         )
@@ -239,7 +245,7 @@ def test_no_op_tracer_provider(self):
 
     def test_executemany(self):
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname", "testcomponent"
+            "instrumenting_module_test_name", "testcomponent"
         )
         mock_connection = db_integration.wrapped_connection(
             mock_connect, {}, {}
@@ -263,7 +269,7 @@ def test_executemany_comment(self):
         connect_module.paramstyle = "test"
 
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "postgresql",
             enable_commenter=True,
             commenter_options={"db_driver": False, "dbapi_level": False},
@@ -296,7 +302,7 @@ def test_executemany_comment_stmt_enabled(self):
         connect_module.paramstyle = "test"
 
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "postgresql",
             enable_commenter=True,
             commenter_options={"db_driver": False, "dbapi_level": False},
@@ -333,7 +339,7 @@ def __getattr__(self, name):
 
         connect_module = MockConnectModule()
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "postgresql",
             enable_commenter=True,
             connect_module=connect_module,
@@ -369,7 +375,7 @@ def __getattr__(self, name):
 
         connect_module = MockConnectModule()
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "postgresql",
             enable_commenter=True,
             connect_module=connect_module,
@@ -404,7 +410,7 @@ def test_executemany_comment_stmt_enabled_matches_db_statement_attribute(
         connect_module.paramstyle = "test"
 
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "postgresql",
             enable_commenter=True,
             commenter_options={"db_driver": False, "dbapi_level": False},
@@ -445,7 +451,7 @@ def test_compatible_build_version_psycopg_psycopg2_libpq(self):
         connect_module.paramstyle = "test"
 
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "postgresql",
             enable_commenter=True,
             commenter_options={"db_driver": False, "dbapi_level": False},
@@ -481,7 +487,7 @@ def test_compatible_build_version_psycopg_psycopg2_libpq_stmt_enabled(
         connect_module.paramstyle = "test"
 
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "postgresql",
             enable_commenter=True,
             commenter_options={"db_driver": False, "dbapi_level": False},
@@ -515,7 +521,7 @@ def test_executemany_psycopg2_integration_comment(self):
         connect_module.paramstyle = "test"
 
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "postgresql",
             enable_commenter=True,
             commenter_options={"db_driver": True, "dbapi_level": False},
@@ -548,7 +554,7 @@ def test_executemany_psycopg2_integration_comment_stmt_enabled(self):
         connect_module.paramstyle = "test"
 
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "postgresql",
             enable_commenter=True,
             commenter_options={"db_driver": True, "dbapi_level": False},
@@ -583,7 +589,7 @@ def test_executemany_psycopg_integration_comment(self):
         connect_module.paramstyle = "test"
 
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "postgresql",
             enable_commenter=True,
             commenter_options={"db_driver": True, "dbapi_level": False},
@@ -617,7 +623,7 @@ def test_executemany_psycopg_integration_comment_stmt_enabled(self):
         connect_module.paramstyle = "test"
 
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "postgresql",
             enable_commenter=True,
             commenter_options={"db_driver": True, "dbapi_level": False},
@@ -650,7 +656,7 @@ def test_executemany_mysqlconnector_integration_comment(self):
         connect_module.paramstyle = "test"
 
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "mysql",
             enable_commenter=True,
             commenter_options={"db_driver": True, "dbapi_level": False},
@@ -683,7 +689,7 @@ def test_executemany_mysqlconnector_integration_comment_stmt_enabled(self):
         connect_module.paramstyle = "test"
 
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "mysql",
             enable_commenter=True,
             commenter_options={"db_driver": True, "dbapi_level": False},
@@ -726,7 +732,7 @@ def test_executemany_mysqlclient_integration_comment(
         )
 
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "mysql",
             enable_commenter=True,
             commenter_options={"db_driver": True, "dbapi_level": False},
@@ -768,7 +774,7 @@ def test_executemany_mysqlclient_integration_comment_stmt_enabled(
         )
 
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "mysql",
             enable_commenter=True,
             commenter_options={"db_driver": True, "dbapi_level": False},
@@ -803,7 +809,7 @@ def test_executemany_pymysql_integration_comment(self):
         connect_module.get_client_info = mock.MagicMock(return_value="123")
 
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "mysql",
             enable_commenter=True,
             commenter_options={"db_driver": True, "dbapi_level": False},
@@ -837,7 +843,7 @@ def test_executemany_pymysql_integration_comment_stmt_enabled(self):
         connect_module.get_client_info = mock.MagicMock(return_value="123")
 
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "mysql",
             enable_commenter=True,
             commenter_options={"db_driver": True, "dbapi_level": False},
@@ -872,7 +878,7 @@ def test_executemany_flask_integration_comment(self):
         connect_module.paramstyle = "test"
 
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "postgresql",
             enable_commenter=True,
             commenter_options={"db_driver": False, "dbapi_level": False},
@@ -916,7 +922,7 @@ def test_executemany_flask_integration_comment_stmt_enabled(self):
         connect_module.paramstyle = "test"
 
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname",
+            "instrumenting_module_test_name",
             "postgresql",
             enable_commenter=True,
             commenter_options={"db_driver": False, "dbapi_level": False},
@@ -953,7 +959,7 @@ def test_executemany_flask_integration_comment_stmt_enabled(self):
 
     def test_callproc(self):
         db_integration = dbapi.DatabaseApiIntegration(
-            "testname", "testcomponent"
+            "instrumenting_module_test_name", "testcomponent"
         )
         mock_connection = db_integration.wrapped_connection(
             mock_connect, {}, {}
@@ -987,15 +993,19 @@ def test_unwrap_connect(self, mock_dbapi):
         self.assertIsInstance(connection, mock.Mock)
 
     def test_instrument_connection(self):
-        connection = mock.Mock()
+        mocked_conn = MockConnection("dbname", "999", "dbhost", "dbuser")
         # Avoid get_attributes failing because can't concatenate mock
-        connection.database = "-"
-        connection2 = dbapi.instrument_connection(self.tracer, connection, "-")
-        self.assertIs(connection2.__wrapped__, connection)
+        connection2 = dbapi.instrument_connection(
+            "instrumenting_module_test_name", mocked_conn, "dbname"
+        )
+        self.assertIs(connection2.__wrapped__, mocked_conn)
 
     @mock.patch("opentelemetry.instrumentation.dbapi.DatabaseApiIntegration")
     def test_instrument_connection_kwargs_defaults(self, mock_dbapiint):
-        dbapi.instrument_connection(self.tracer, mock.Mock(), "foo")
+        mocked_conn = MockConnection("dbname", "999", "dbhost", "dbuser")
+        dbapi.instrument_connection(
+            "instrumenting_module_test_name", mocked_conn, "foo"
+        )
         kwargs = mock_dbapiint.call_args[1]
         self.assertEqual(kwargs["connection_attributes"], None)
         self.assertEqual(kwargs["version"], "")
@@ -1008,11 +1018,12 @@ def test_instrument_connection_kwargs_defaults(self, mock_dbapiint):
 
     @mock.patch("opentelemetry.instrumentation.dbapi.DatabaseApiIntegration")
     def test_instrument_connection_kwargs_provided(self, mock_dbapiint):
+        mocked_conn = MockConnection("dbname", "999", "dbhost", "dbuser")
         mock_tracer_provider = mock.MagicMock()
         mock_connect_module = mock.MagicMock()
         dbapi.instrument_connection(
-            self.tracer,
-            mock.Mock(),
+            "instrumenting_module_test_name",
+            mocked_conn,
             "foo",
             connection_attributes={"foo": "bar"},
             version="test",
@@ -1033,20 +1044,35 @@ def test_instrument_connection_kwargs_provided(self, mock_dbapiint):
         self.assertIs(kwargs["connect_module"], mock_connect_module)
         self.assertEqual(kwargs["enable_attribute_commenter"], True)
 
+    def test_instrument_connection_db_api_integration_factory(self):
+        mocked_conn = MockConnection("dbname", "999", "dbhost", "dbuser")
+
+        class DBApiIntegrationTestClass(dbapi.DatabaseApiIntegration):
+            pass
+
+        conn = dbapi.instrument_connection(
+            "instrumenting_module_test_name",
+            mocked_conn,
+            "dbsystem",
+            db_api_integration_factory=DBApiIntegrationTestClass,
+        )
+        self.assertIsInstance(
+            conn._self_db_api_integration, DBApiIntegrationTestClass
+        )
+
     def test_uninstrument_connection(self):
-        connection = mock.Mock()
-        # Set connection.database to avoid a failure because mock can't
-        # be concatenated
-        connection.database = "-"
-        connection2 = dbapi.instrument_connection(self.tracer, connection, "-")
-        self.assertIs(connection2.__wrapped__, connection)
+        mocked_conn = MockConnection("dbname", "999", "dbhost", "dbuser")
+        connection2 = dbapi.instrument_connection(
+            "instrumenting_module_test_name", mocked_conn, "-"
+        )
+        self.assertIs(connection2.__wrapped__, mocked_conn)
 
         connection3 = dbapi.uninstrument_connection(connection2)
-        self.assertIs(connection3, connection)
+        self.assertIs(connection3, mocked_conn)
 
         with self.assertLogs(level=logging.WARNING):
-            connection4 = dbapi.uninstrument_connection(connection)
-        self.assertIs(connection4, connection)
+            connection4 = dbapi.uninstrument_connection(mocked_conn)
+        self.assertIs(connection4, mocked_conn)
 
 
 # pylint: disable=unused-argument
diff --git a/instrumentation/opentelemetry-instrumentation-pymssql/LICENSE b/instrumentation/opentelemetry-instrumentation-pymssql/LICENSE
new file mode 100644
index 0000000000..261eeb9e9f
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-pymssql/LICENSE
@@ -0,0 +1,201 @@
+                                 Apache License
+                           Version 2.0, January 2004
+                        http://www.apache.org/licenses/
+
+   TERMS AND CONDITIONS FOR USE, REPRODUCTION, AND DISTRIBUTION
+
+   1. Definitions.
+
+      "License" shall mean the terms and conditions for use, reproduction,
+      and distribution as defined by Sections 1 through 9 of this document.
+
+      "Licensor" shall mean the copyright owner or entity authorized by
+      the copyright owner that is granting the License.
+
+      "Legal Entity" shall mean the union of the acting entity and all
+      other entities that control, are controlled by, or are under common
+      control with that entity. For the purposes of this definition,
+      "control" means (i) the power, direct or indirect, to cause the
+      direction or management of such entity, whether by contract or
+      otherwise, or (ii) ownership of fifty percent (50%) or more of the
+      outstanding shares, or (iii) beneficial ownership of such entity.
+
+      "You" (or "Your") shall mean an individual or Legal Entity
+      exercising permissions granted by this License.
+
+      "Source" form shall mean the preferred form for making modifications,
+      including but not limited to software source code, documentation
+      source, and configuration files.
+
+      "Object" form shall mean any form resulting from mechanical
+      transformation or translation of a Source form, including but
+      not limited to compiled object code, generated documentation,
+      and conversions to other media types.
+
+      "Work" shall mean the work of authorship, whether in Source or
+      Object form, made available under the License, as indicated by a
+      copyright notice that is included in or attached to the work
+      (an example is provided in the Appendix below).
+
+      "Derivative Works" shall mean any work, whether in Source or Object
+      form, that is based on (or derived from) the Work and for which the
+      editorial revisions, annotations, elaborations, or other modifications
+      represent, as a whole, an original work of authorship. For the purposes
+      of this License, Derivative Works shall not include works that remain
+      separable from, or merely link (or bind by name) to the interfaces of,
+      the Work and Derivative Works thereof.
+
+      "Contribution" shall mean any work of authorship, including
+      the original version of the Work and any modifications or additions
+      to that Work or Derivative Works thereof, that is intentionally
+      submitted to Licensor for inclusion in the Work by the copyright owner
+      or by an individual or Legal Entity authorized to submit on behalf of
+      the copyright owner. For the purposes of this definition, "submitted"
+      means any form of electronic, verbal, or written communication sent
+      to the Licensor or its representatives, including but not limited to
+      communication on electronic mailing lists, source code control systems,
+      and issue tracking systems that are managed by, or on behalf of, the
+      Licensor for the purpose of discussing and improving the Work, but
+      excluding communication that is conspicuously marked or otherwise
+      designated in writing by the copyright owner as "Not a Contribution."
+
+      "Contributor" shall mean Licensor and any individual or Legal Entity
+      on behalf of whom a Contribution has been received by Licensor and
+      subsequently incorporated within the Work.
+
+   2. Grant of Copyright License. Subject to the terms and conditions of
+      this License, each Contributor hereby grants to You a perpetual,
+      worldwide, non-exclusive, no-charge, royalty-free, irrevocable
+      copyright license to reproduce, prepare Derivative Works of,
+      publicly display, publicly perform, sublicense, and distribute the
+      Work and such Derivative Works in Source or Object form.
+
+   3. Grant of Patent License. Subject to the terms and conditions of
+      this License, each Contributor hereby grants to You a perpetual,
+      worldwide, non-exclusive, no-charge, royalty-free, irrevocable
+      (except as stated in this section) patent license to make, have made,
+      use, offer to sell, sell, import, and otherwise transfer the Work,
+      where such license applies only to those patent claims licensable
+      by such Contributor that are necessarily infringed by their
+      Contribution(s) alone or by combination of their Contribution(s)
+      with the Work to which such Contribution(s) was submitted. If You
+      institute patent litigation against any entity (including a
+      cross-claim or counterclaim in a lawsuit) alleging that the Work
+      or a Contribution incorporated within the Work constitutes direct
+      or contributory patent infringement, then any patent licenses
+      granted to You under this License for that Work shall terminate
+      as of the date such litigation is filed.
+
+   4. Redistribution. You may reproduce and distribute copies of the
+      Work or Derivative Works thereof in any medium, with or without
+      modifications, and in Source or Object form, provided that You
+      meet the following conditions:
+
+      (a) You must give any other recipients of the Work or
+          Derivative Works a copy of this License; and
+
+      (b) You must cause any modified files to carry prominent notices
+          stating that You changed the files; and
+
+      (c) You must retain, in the Source form of any Derivative Works
+          that You distribute, all copyright, patent, trademark, and
+          attribution notices from the Source form of the Work,
+          excluding those notices that do not pertain to any part of
+          the Derivative Works; and
+
+      (d) If the Work includes a "NOTICE" text file as part of its
+          distribution, then any Derivative Works that You distribute must
+          include a readable copy of the attribution notices contained
+          within such NOTICE file, excluding those notices that do not
+          pertain to any part of the Derivative Works, in at least one
+          of the following places: within a NOTICE text file distributed
+          as part of the Derivative Works; within the Source form or
+          documentation, if provided along with the Derivative Works; or,
+          within a display generated by the Derivative Works, if and
+          wherever such third-party notices normally appear. The contents
+          of the NOTICE file are for informational purposes only and
+          do not modify the License. You may add Your own attribution
+          notices within Derivative Works that You distribute, alongside
+          or as an addendum to the NOTICE text from the Work, provided
+          that such additional attribution notices cannot be construed
+          as modifying the License.
+
+      You may add Your own copyright statement to Your modifications and
+      may provide additional or different license terms and conditions
+      for use, reproduction, or distribution of Your modifications, or
+      for any such Derivative Works as a whole, provided Your use,
+      reproduction, and distribution of the Work otherwise complies with
+      the conditions stated in this License.
+
+   5. Submission of Contributions. Unless You explicitly state otherwise,
+      any Contribution intentionally submitted for inclusion in the Work
+      by You to the Licensor shall be under the terms and conditions of
+      this License, without any additional terms or conditions.
+      Notwithstanding the above, nothing herein shall supersede or modify
+      the terms of any separate license agreement you may have executed
+      with Licensor regarding such Contributions.
+
+   6. Trademarks. This License does not grant permission to use the trade
+      names, trademarks, service marks, or product names of the Licensor,
+      except as required for reasonable and customary use in describing the
+      origin of the Work and reproducing the content of the NOTICE file.
+
+   7. Disclaimer of Warranty. Unless required by applicable law or
+      agreed to in writing, Licensor provides the Work (and each
+      Contributor provides its Contributions) on an "AS IS" BASIS,
+      WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or
+      implied, including, without limitation, any warranties or conditions
+      of TITLE, NON-INFRINGEMENT, MERCHANTABILITY, or FITNESS FOR A
+      PARTICULAR PURPOSE. You are solely responsible for determining the
+      appropriateness of using or redistributing the Work and assume any
+      risks associated with Your exercise of permissions under this License.
+
+   8. Limitation of Liability. In no event and under no legal theory,
+      whether in tort (including negligence), contract, or otherwise,
+      unless required by applicable law (such as deliberate and grossly
+      negligent acts) or agreed to in writing, shall any Contributor be
+      liable to You for damages, including any direct, indirect, special,
+      incidental, or consequential damages of any character arising as a
+      result of this License or out of the use or inability to use the
+      Work (including but not limited to damages for loss of goodwill,
+      work stoppage, computer failure or malfunction, or any and all
+      other commercial damages or losses), even if such Contributor
+      has been advised of the possibility of such damages.
+
+   9. Accepting Warranty or Additional Liability. While redistributing
+      the Work or Derivative Works thereof, You may choose to offer,
+      and charge a fee for, acceptance of support, warranty, indemnity,
+      or other liability obligations and/or rights consistent with this
+      License. However, in accepting such obligations, You may act only
+      on Your own behalf and on Your sole responsibility, not on behalf
+      of any other Contributor, and only if You agree to indemnify,
+      defend, and hold each Contributor harmless for any liability
+      incurred by, or claims asserted against, such Contributor by reason
+      of your accepting any such warranty or additional liability.
+
+   END OF TERMS AND CONDITIONS
+
+   APPENDIX: How to apply the Apache License to your work.
+
+      To apply the Apache License to your work, attach the following
+      boilerplate notice, with the fields enclosed by brackets "[]"
+      replaced with your own identifying information. (Don't include
+      the brackets!)  The text should be enclosed in the appropriate
+      comment syntax for the file format. We also recommend that a
+      file or class name and description of purpose be included on the
+      same "printed page" as the copyright notice for easier
+      identification within third-party archives.
+
+   Copyright [yyyy] [name of copyright owner]
+
+   Licensed under the Apache License, Version 2.0 (the "License");
+   you may not use this file except in compliance with the License.
+   You may obtain a copy of the License at
+
+       http://www.apache.org/licenses/LICENSE-2.0
+
+   Unless required by applicable law or agreed to in writing, software
+   distributed under the License is distributed on an "AS IS" BASIS,
+   WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+   See the License for the specific language governing permissions and
+   limitations under the License.
diff --git a/instrumentation/opentelemetry-instrumentation-pymssql/README.rst b/instrumentation/opentelemetry-instrumentation-pymssql/README.rst
new file mode 100644
index 0000000000..b885d6b5c5
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-pymssql/README.rst
@@ -0,0 +1,21 @@
+OpenTelemetry pymssql Instrumentation
+=====================================
+
+|pypi|
+
+.. |pypi| image:: https://badge.fury.io/py/opentelemetry-instrumentation-pymssql.svg
+   :target: https://pypi.org/project/opentelemetry-instrumentation-pymssql/
+
+Installation
+------------
+
+::
+
+    pip install opentelemetry-instrumentation-pymssql
+
+
+References
+----------
+* `OpenTelemetry pymssql Instrumentation <https://opentelemetry-python-contrib.readthedocs.io/en/latest/instrumentation/pymssql/pymssql.html>`_
+* `OpenTelemetry Project <https://opentelemetry.io/>`_
+* `OpenTelemetry Python Examples <https://github.com/open-telemetry/opentelemetry-python/tree/main/docs/examples>`_
diff --git a/instrumentation/opentelemetry-instrumentation-pymssql/pyproject.toml b/instrumentation/opentelemetry-instrumentation-pymssql/pyproject.toml
new file mode 100644
index 0000000000..5360007a5c
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-pymssql/pyproject.toml
@@ -0,0 +1,56 @@
+[build-system]
+requires = ["hatchling"]
+build-backend = "hatchling.build"
+
+[project]
+name = "opentelemetry-instrumentation-pymssql"
+dynamic = ["version"]
+description = "OpenTelemetry pymssql instrumentation"
+readme = "README.rst"
+license = "Apache-2.0"
+requires-python = ">=3.8"
+authors = [
+  { name = "OpenTelemetry Authors", email = "cncf-opentelemetry-contributors@lists.cncf.io" },
+]
+classifiers = [
+  "Development Status :: 4 - Beta",
+  "Intended Audience :: Developers",
+  "License :: OSI Approved :: Apache Software License",
+  "Programming Language :: Python",
+  "Programming Language :: Python :: 3",
+  "Programming Language :: Python :: 3.8",
+  "Programming Language :: Python :: 3.9",
+  "Programming Language :: Python :: 3.10",
+  "Programming Language :: Python :: 3.11",
+  "Programming Language :: Python :: 3.12",
+  "Programming Language :: Python :: 3.13",
+]
+dependencies = [
+  "opentelemetry-api ~= 1.12",
+  "opentelemetry-instrumentation == 0.51b0.dev",
+  "opentelemetry-instrumentation-dbapi == 0.51b0.dev",
+]
+
+[project.optional-dependencies]
+instruments = [
+  "pymssql >= 2.1.5, < 3",
+]
+
+[project.entry-points.opentelemetry_instrumentor]
+pymssql = "opentelemetry.instrumentation.pymssql:pymssqlInstrumentor"
+
+[project.urls]
+Homepage = "https://github.com/open-telemetry/opentelemetry-python-contrib/tree/main/instrumentation/opentelemetry-instrumentation-pymssql"
+Repository = "https://github.com/open-telemetry/opentelemetry-python-contrib"
+
+[tool.hatch.version]
+path = "src/opentelemetry/instrumentation/pymssql/version.py"
+
+[tool.hatch.build.targets.sdist]
+include = [
+  "/src",
+  "/tests",
+]
+
+[tool.hatch.build.targets.wheel]
+packages = ["src/opentelemetry"]
diff --git a/instrumentation/opentelemetry-instrumentation-pymssql/src/opentelemetry/instrumentation/pymssql/__init__.py b/instrumentation/opentelemetry-instrumentation-pymssql/src/opentelemetry/instrumentation/pymssql/__init__.py
new file mode 100644
index 0000000000..2f2ca5f4a2
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-pymssql/src/opentelemetry/instrumentation/pymssql/__init__.py
@@ -0,0 +1,208 @@
+# Copyright The OpenTelemetry Authors
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+"""
+The integration with pymssql supports the `pymssql`_ library and can be enabled
+by using ``PyMSSQLInstrumentor``.
+
+.. _pymssql: https://pypi.org/project/pymssql/
+
+Usage
+-----
+
+.. code:: python
+
+    import pymssql
+    from opentelemetry.instrumentation.pymssql import PyMSSQLInstrumentor
+
+    PyMSSQLInstrumentor().instrument()
+
+    cnx = pymssql.connect(database="MSSQL_Database")
+    cursor = cnx.cursor()
+    cursor.execute("INSERT INTO test (testField) VALUES (123)"
+    cnx.commit()
+    cursor.close()
+    cnx.close()
+
+.. code:: python
+
+    import pymssql
+    from opentelemetry.instrumentation.pymssql import PyMSSQLInstrumentor
+
+    # Alternatively, use instrument_connection for an individual connection
+    cnx = pymssql.connect(database="MSSQL_Database")
+    instrumented_cnx = PyMSSQLInstrumentor().instrument_connection(cnx)
+    cursor = instrumented_cnx.cursor()
+    cursor.execute("INSERT INTO test (testField) VALUES (123)"
+    instrumented_cnx.commit()
+    cursor.close()
+    instrumented_cnx.close()
+
+API
+---
+The `instrument` method accepts the following keyword args:
+
+tracer_provider (TracerProvider) - an optional tracer provider
+
+For example:
+
+.. code: python
+
+    import pymssql
+    from opentelemetry.instrumentation.pymssql import PyMSSQLInstrumentor
+    from opentelemetry.trace import NoOpTracerProvider
+
+    PyMSSQLInstrumentor().instrument(tracer_provider=NoOpTracerProvider())
+"""
+
+from __future__ import annotations
+
+from typing import Any, Callable, Collection, NamedTuple
+
+import pymssql
+
+from opentelemetry.instrumentation import dbapi
+from opentelemetry.instrumentation.instrumentor import BaseInstrumentor
+from opentelemetry.instrumentation.pymssql.package import _instruments
+from opentelemetry.instrumentation.pymssql.version import __version__
+
+_DATABASE_SYSTEM = "mssql"
+
+
+class _PyMSSQLConnectMethodArgsTuple(NamedTuple):
+    server: str | None = None
+    user: str | None = None
+    password: str | None = None
+    database: str | None = None
+    timeout: int | None = None
+    login_timeout: int | None = None
+    charset: str | None = None
+    as_dict: bool | None = None
+    host: str | None = None
+    appname: str | None = None
+    port: str | None = None
+    conn_properties: str | None = None
+    autocommit: bool | None = None
+    tds_version: str | None = None
+
+
+class _PyMSSQLDatabaseApiIntegration(dbapi.DatabaseApiIntegration):
+    def wrapped_connection(
+        self,
+        connect_method: Callable[..., Any],
+        args: tuple[Any, Any],
+        kwargs: dict[Any, Any],
+    ):
+        """Add object proxy to connection object."""
+        connection = connect_method(*args, **kwargs)
+        connect_method_args = _PyMSSQLConnectMethodArgsTuple(*args)
+
+        self.name = self.database_system
+        self.database = kwargs.get("database") or connect_method_args.database
+
+        user = kwargs.get("user") or connect_method_args.user
+        if user is not None:
+            self.span_attributes["db.user"] = user
+
+        port = kwargs.get("port") or connect_method_args.port
+        host = kwargs.get("server") or connect_method_args.server
+        if host is None:
+            host = kwargs.get("host") or connect_method_args.host
+        if host is not None:
+            # The host string can include the port, separated by either a coma or
+            # a column
+            for sep in (":", ","):
+                if sep in host:
+                    tokens = host.rsplit(sep)
+                    host = tokens[0]
+                    if len(tokens) > 1:
+                        port = tokens[1]
+        if host is not None:
+            self.span_attributes["net.peer.name"] = host
+        if port is not None:
+            self.span_attributes["net.peer.port"] = port
+
+        charset = kwargs.get("charset") or connect_method_args.charset
+        if charset is not None:
+            self.span_attributes["db.charset"] = charset
+
+        tds_version = (
+            kwargs.get("tds_version") or connect_method_args.tds_version
+        )
+        if tds_version is not None:
+            self.span_attributes["db.protocol.tds.version"] = tds_version
+
+        return dbapi.get_traced_connection_proxy(connection, self)
+
+
+class PyMSSQLInstrumentor(BaseInstrumentor):
+    def instrumentation_dependencies(self) -> Collection[str]:
+        return _instruments
+
+    def _instrument(self, **kwargs):
+        """Integrate with the pymssql library.
+        https://github.com/pymssql/pymssql/
+        """
+        tracer_provider = kwargs.get("tracer_provider")
+
+        dbapi.wrap_connect(
+            __name__,
+            pymssql,
+            "connect",
+            _DATABASE_SYSTEM,
+            version=__version__,
+            tracer_provider=tracer_provider,
+            # pymssql does not keep the connection attributes in its connection object;
+            # instead, we get the attributes from the connect method (which is done
+            # via PyMSSQLDatabaseApiIntegration.wrapped_connection)
+            db_api_integration_factory=_PyMSSQLDatabaseApiIntegration,
+        )
+
+    def _uninstrument(self, **kwargs):
+        """ "Disable pymssql instrumentation"""
+        dbapi.unwrap_connect(pymssql, "connect")
+
+    @staticmethod
+    def instrument_connection(connection, tracer_provider=None):
+        """Enable instrumentation in a pymssql connection.
+
+        Args:
+            connection: The connection to instrument.
+            tracer_provider: The optional tracer provider to use. If omitted
+                the current globally configured one is used.
+
+        Returns:
+            An instrumented connection.
+        """
+
+        return dbapi.instrument_connection(
+            __name__,
+            connection,
+            _DATABASE_SYSTEM,
+            version=__version__,
+            tracer_provider=tracer_provider,
+            db_api_integration_factory=_PyMSSQLDatabaseApiIntegration,
+        )
+
+    @staticmethod
+    def uninstrument_connection(connection):
+        """Disable instrumentation in a pymssql connection.
+
+        Args:
+            connection: The connection to uninstrument.
+
+        Returns:
+            An uninstrumented connection.
+        """
+        return dbapi.uninstrument_connection(connection)
diff --git a/instrumentation/opentelemetry-instrumentation-pymssql/src/opentelemetry/instrumentation/pymssql/package.py b/instrumentation/opentelemetry-instrumentation-pymssql/src/opentelemetry/instrumentation/pymssql/package.py
new file mode 100644
index 0000000000..92bc9e0193
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-pymssql/src/opentelemetry/instrumentation/pymssql/package.py
@@ -0,0 +1,16 @@
+# Copyright The OpenTelemetry Authors
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+
+_instruments = ("pymssql >= 2.1.5, < 3",)
diff --git a/instrumentation/opentelemetry-instrumentation-pymssql/src/opentelemetry/instrumentation/pymssql/version.py b/instrumentation/opentelemetry-instrumentation-pymssql/src/opentelemetry/instrumentation/pymssql/version.py
new file mode 100644
index 0000000000..6e2923f0db
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-pymssql/src/opentelemetry/instrumentation/pymssql/version.py
@@ -0,0 +1,15 @@
+# Copyright The OpenTelemetry Authors
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+__version__ = "0.51b0.dev"
diff --git a/instrumentation/opentelemetry-instrumentation-pymssql/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-pymssql/test-requirements.txt
new file mode 100644
index 0000000000..19e4bb3e3f
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-pymssql/test-requirements.txt
@@ -0,0 +1,10 @@
+exceptiongroup==1.2.2
+iniconfig==2.0.0
+packaging==24.2
+pluggy==1.5.0
+pymssql==2.3.1
+pytest==7.4.4
+tomli==2.2.1
+-e opentelemetry-instrumentation
+-e instrumentation/opentelemetry-instrumentation-dbapi
+-e instrumentation/opentelemetry-instrumentation-pymssql
diff --git a/instrumentation/opentelemetry-instrumentation-pymssql/tests/__init__.py b/instrumentation/opentelemetry-instrumentation-pymssql/tests/__init__.py
new file mode 100644
index 0000000000..e69de29bb2
diff --git a/instrumentation/opentelemetry-instrumentation-pymssql/tests/test_pymssql_integration.py b/instrumentation/opentelemetry-instrumentation-pymssql/tests/test_pymssql_integration.py
new file mode 100644
index 0000000000..ccd522b165
--- /dev/null
+++ b/instrumentation/opentelemetry-instrumentation-pymssql/tests/test_pymssql_integration.py
@@ -0,0 +1,184 @@
+# Copyright The OpenTelemetry Authors
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+from unittest.mock import Mock, patch
+
+import pymssql  # type: ignore
+
+import opentelemetry.instrumentation.pymssql
+from opentelemetry.instrumentation.pymssql import PyMSSQLInstrumentor
+from opentelemetry.sdk import resources
+from opentelemetry.test.test_base import TestBase
+
+
+def mock_connect(*args, **kwargs):
+    class MockConnection:
+        def cursor(self):
+            # pylint: disable=no-self-use
+            return Mock()
+
+    return MockConnection()
+
+
+class TestPyMSSQLIntegration(TestBase):
+    def tearDown(self):
+        super().tearDown()
+        with self.disable_logging():
+            PyMSSQLInstrumentor().uninstrument()
+
+    def _execute_query_and_get_span(self, cnx):
+        cursor = cnx.cursor()
+        query = "SELECT * FROM test"
+        cursor.execute(query)
+
+        spans_list = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans_list), 1)
+        span = spans_list[0]
+
+        # Check version and name in span's instrumentation info
+        self.assertEqualSpanInstrumentationScope(
+            span, opentelemetry.instrumentation.pymssql
+        )
+        return span
+
+    @patch("pymssql.connect", new=mock_connect)
+    # pylint: disable=unused-argument
+    def test_instrumentor(self):
+        PyMSSQLInstrumentor().instrument()
+
+        cnx = pymssql.connect(  # pylint: disable=no-member
+            host="dbserver.local:1433",
+            database="testdb",
+            user="dbuser",
+            password="dbpassw0rd",
+            charset="UTF-8",
+            tds_version="7.1",
+        )
+        span = self._execute_query_and_get_span(cnx)
+
+        self.assertEqual(span.attributes["db.system"], "mssql")
+        self.assertEqual(span.attributes["db.name"], "testdb")
+        self.assertEqual(span.attributes["db.statement"], "SELECT * FROM test")
+        self.assertEqual(span.attributes["db.user"], "dbuser")
+        self.assertEqual(span.attributes["net.peer.name"], "dbserver.local")
+        self.assertEqual(span.attributes["net.peer.port"], "1433")
+        self.assertEqual(span.attributes["db.charset"], "UTF-8")
+        self.assertEqual(span.attributes["db.protocol.tds.version"], "7.1")
+
+        # check that no spans are generated after uninstrument
+        PyMSSQLInstrumentor().uninstrument()
+
+        cnx = pymssql.connect(database="test")  # pylint: disable=no-member
+        cursor = cnx.cursor()
+        query = "SELECT * FROM test"
+        cursor.execute(query)
+
+        spans_list = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans_list), 1)
+
+    @patch("pymssql.connect", new=mock_connect)
+    # pylint: disable=unused-argument
+    def test_instrumentor_server_param(self):
+        PyMSSQLInstrumentor().instrument()
+
+        # `server` can be used instead of `host`
+        cnx = pymssql.connect(server="dbserver.local:1433", database="testdb")  # pylint: disable=no-member
+        span = self._execute_query_and_get_span(cnx)
+
+        self.assertEqual(span.attributes["net.peer.name"], "dbserver.local")
+        self.assertEqual(span.attributes["net.peer.port"], "1433")
+
+    @patch("pymssql.connect", new=mock_connect)
+    # pylint: disable=unused-argument
+    def test_instrumentor_port_param(self):
+        PyMSSQLInstrumentor().instrument()
+
+        # port can be specified as a parameter
+        cnx = pymssql.connect(  # pylint: disable=no-member
+            server="dbserver.local", port="1433", database="testdb"
+        )
+        span = self._execute_query_and_get_span(cnx)
+
+        self.assertEqual(span.attributes["net.peer.name"], "dbserver.local")
+        self.assertEqual(span.attributes["net.peer.port"], "1433")
+
+    @patch("pymssql.connect", new=mock_connect)
+    # pylint: disable=unused-argument
+    def test_instrumentor_windows_server(self):
+        PyMSSQLInstrumentor().instrument()
+
+        # Windows server names can include special characters
+        cnx = pymssql.connect(server=r"(local)\SQLEXPRESS", database="testdb")  # pylint: disable=no-member
+        span = self._execute_query_and_get_span(cnx)
+
+        self.assertEqual(
+            span.attributes["net.peer.name"], r"(local)\SQLEXPRESS"
+        )
+
+    @patch("pymssql.connect", new=mock_connect)
+    # pylint: disable=unused-argument
+    def test_custom_tracer_provider(self):
+        resource = resources.Resource.create({})
+        result = self.create_tracer_provider(resource=resource)
+        tracer_provider, exporter = result
+
+        PyMSSQLInstrumentor().instrument(tracer_provider=tracer_provider)
+
+        cnx = pymssql.connect(database="test")  # pylint: disable=no-member
+        cursor = cnx.cursor()
+        query = "SELECT * FROM test"
+        cursor.execute(query)
+
+        spans_list = exporter.get_finished_spans()
+        self.assertEqual(len(spans_list), 1)
+        span = spans_list[0]
+
+        self.assertIs(span.resource, resource)
+
+    @patch("pymssql.connect", new=mock_connect)
+    # pylint: disable=unused-argument
+    def test_instrument_connection(self):
+        cnx = pymssql.connect(database="test")  # pylint: disable=no-member
+        query = "SELECT * FROM test"
+        cursor = cnx.cursor()
+        cursor.execute(query)
+
+        spans_list = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans_list), 0)
+
+        cnx = PyMSSQLInstrumentor().instrument_connection(cnx)
+        cursor = cnx.cursor()
+        cursor.execute(query)
+
+        spans_list = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans_list), 1)
+
+    @patch("pymssql.connect", new=mock_connect)
+    # pylint: disable=unused-argument
+    def test_uninstrument_connection(self):
+        PyMSSQLInstrumentor().instrument()
+        cnx = pymssql.connect(database="test")  # pylint: disable=no-member
+        query = "SELECT * FROM test"
+        cursor = cnx.cursor()
+        cursor.execute(query)
+
+        spans_list = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans_list), 1)
+
+        cnx = PyMSSQLInstrumentor().uninstrument_connection(cnx)
+        cursor = cnx.cursor()
+        cursor.execute(query)
+
+        spans_list = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(spans_list), 1)
diff --git a/opentelemetry-contrib-instrumentations/pyproject.toml b/opentelemetry-contrib-instrumentations/pyproject.toml
index e19c0d69d8..9c0ab886d5 100644
--- a/opentelemetry-contrib-instrumentations/pyproject.toml
+++ b/opentelemetry-contrib-instrumentations/pyproject.toml
@@ -64,6 +64,7 @@ dependencies = [
     "opentelemetry-instrumentation-psycopg2==0.51b0.dev",
     "opentelemetry-instrumentation-pymemcache==0.51b0.dev",
     "opentelemetry-instrumentation-pymongo==0.51b0.dev",
+    "opentelemetry-instrumentation-pymssql==0.51b0.dev",
     "opentelemetry-instrumentation-pymysql==0.51b0.dev",
     "opentelemetry-instrumentation-pyramid==0.51b0.dev",
     "opentelemetry-instrumentation-redis==0.51b0.dev",
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
index cea9e3e11f..f28ebfb41b 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
@@ -156,6 +156,10 @@
         "library": "pymongo >= 3.1, < 5.0",
         "instrumentation": "opentelemetry-instrumentation-pymongo==0.51b0.dev",
     },
+    {
+        "library": "pymssql >= 2.1.5, < 3",
+        "instrumentation": "opentelemetry-instrumentation-pymssql==0.51b0.dev",
+    },
     {
         "library": "PyMySQL < 2",
         "instrumentation": "opentelemetry-instrumentation-pymysql==0.51b0.dev",
diff --git a/tox.ini b/tox.ini
index 22e56a835f..b45b6b4d4c 100644
--- a/tox.ini
+++ b/tox.ini
@@ -243,6 +243,12 @@ envlist =
     pypy3-test-instrumentation-pymysql
     lint-instrumentation-pymysql
 
+    ; opentelemetry-instrumentation-pymssql
+    py3{8,9,10,11,12,13}-test-instrumentation-pymssql
+    ; pymssql has no support for pypy: see https://github.com/pymssql/pymssql/pull/517
+    ; pypy3-test-instrumentation-pymssql
+    lint-instrumentation-pymssql
+
     ; opentelemetry-instrumentation-pyramid
     ; TODO: add py313 when supported by pyramid
     py3{8,9,10,11,12}-test-instrumentation-pyramid
@@ -581,6 +587,9 @@ deps =
   pymysql: {[testenv]test_deps}
   pymysql: -r {toxinidir}/instrumentation/opentelemetry-instrumentation-pymysql/test-requirements.txt
 
+  pymssql: {[testenv]test_deps}
+  pymssql: -r {toxinidir}/instrumentation/opentelemetry-instrumentation-pymssql/test-requirements.txt
+
   pyramid: {[testenv]test_deps}
   pyramid: -r {toxinidir}/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt
 
@@ -829,6 +838,9 @@ commands =
   test-instrumentation-pymysql: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-pymysql/tests {posargs}
   lint-instrumentation-pymysql: sh -c "cd instrumentation && pylint --rcfile ../.pylintrc opentelemetry-instrumentation-pymysql"
 
+  test-instrumentation-pymssql: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-pymssql/tests {posargs}
+  lint-instrumentation-pymssql: sh -c "cd instrumentation && pylint --rcfile ../.pylintrc opentelemetry-instrumentation-pymssql"
+
   test-instrumentation-pyramid: pytest {toxinidir}/instrumentation/opentelemetry-instrumentation-pyramid/tests {posargs}
   lint-instrumentation-pyramid: sh -c "cd instrumentation && pylint --rcfile ../.pylintrc opentelemetry-instrumentation-pyramid"
 
@@ -944,6 +956,7 @@ deps =
   -e {toxinidir}/instrumentation/opentelemetry-instrumentation-psycopg2
   -e {toxinidir}/instrumentation/opentelemetry-instrumentation-pymongo
   -e {toxinidir}/instrumentation/opentelemetry-instrumentation-pymysql
+  -e {toxinidir}/instrumentation/opentelemetry-instrumentation-pymssql
   -e {toxinidir}/instrumentation/opentelemetry-instrumentation-sqlalchemy
   -e {toxinidir}/instrumentation/opentelemetry-instrumentation-aiopg
   -e {toxinidir}/instrumentation/opentelemetry-instrumentation-redis