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Copy pathv3.0.1_optimized.sbml
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v3.0.1_optimized.sbml
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<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level3/version1/core" level="3" version="1">
<model id="cell_cycle_v3_0_1" substanceUnits="substance" timeUnits="second" volumeUnits="volume" areaUnits="area" lengthUnits="metre" extentUnits="substance">
<listOfUnitDefinitions>
<unitDefinition id="volume">
<listOfUnits>
<unit kind="litre" exponent="1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="substance">
<listOfUnits>
<unit kind="mole" exponent="1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="area">
<listOfUnits>
<unit kind="metre" exponent="2" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment id="cell" spatialDimensions="3" size="1" units="volume" constant="true"/>
</listOfCompartments>
<listOfSpecies>
<species id="_cell__CCND" name="_cell__CCND" compartment="cell" initialConcentration="2.161246988" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNE" name="_cell__CCNE" compartment="cell" initialConcentration="0.152805873" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_RB1_Ser332u_" name="_cell__E2F_DBD_RB1_Ser332u_" compartment="cell" initialConcentration="0.00270474" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_RB1_Ser332p_" name="_cell__E2F_DBD_RB1_Ser332p_" compartment="cell" initialConcentration="0.010237" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNA" name="_cell__CCNA" compartment="cell" initialConcentration="0.057913862" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNB_CDK1_Thr14_Tyr15u_" name="_cell__CCNB_CDK1_Thr14_Tyr15u_" compartment="cell" initialConcentration="0.221986967" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" name="_cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" compartment="cell" initialConcentration="0.019501354" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" name="_cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" compartment="cell" initialConcentration="0.028322647" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__RB1_E2F_Ser807_Ser811u_" name="_cell__RB1_E2F_Ser807_Ser811u_" compartment="cell" initialConcentration="0.673236729" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__RB1_E2F_Ser807_Ser811p_" name="_cell__RB1_E2F_Ser807_Ser811p_" compartment="cell" initialConcentration="0.628824522" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__PPP2R2B_ENSA_ARPP19_" name="_cell__PPP2R2B_ENSA_ARPP19_" compartment="cell" initialConcentration="0.003241407" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__APC_FBXO5_FZR1_CDC20_Ser355u_" name="_cell__APC_FBXO5_FZR1_CDC20_Ser355u_" compartment="cell" initialConcentration="35.85843061" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDC20_APC_" name="_cell__CDC20_APC_" compartment="cell" initialConcentration="0.171458508" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__APC_FBXO5_FZR1_CDC20_1_Ser355p__CDC20_APC_1_" name="_cell__APC_FBXO5_FZR1_CDC20_1_Ser355p__CDC20_APC_1_" compartment="cell" initialConcentration="2.664042581" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__APC_FBXO5_FZR1_CDC20_Ser355p_" name="_cell__APC_FBXO5_FZR1_CDC20_Ser355p_" compartment="cell" initialConcentration="2.035839871" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__APC_FBXO5_FZR1_CDC20_1_Ser355u__FZR1_APC_1_FBXO5_nTermu_" name="_cell__APC_FBXO5_FZR1_CDC20_1_Ser355u__FZR1_APC_1_FBXO5_nTermu_" compartment="cell" initialConcentration="0.155358712" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__FZR1_APC_FBXO5_nTermu_" name="_cell__FZR1_APC_FBXO5_nTermu_" compartment="cell" initialConcentration="0.008985317" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__FZR1_APC_FBXO5_nTermp_" name="_cell__FZR1_APC_FBXO5_nTermp_" compartment="cell" initialConcentration="2.851131503" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__APC_FBXO5_1_FZR1_CDC20_2_Ser355u__FBXO5_APC_1_FZR1_3_Ser182u__FZR1_APC_2_FBXO5_3_nTermu_" name="_cell__APC_FBXO5_1_FZR1_CDC20_2_Ser355u__FBXO5_APC_1_FZR1_3_Ser182u__FZR1_APC_2_FBXO5_3_nTermu_" compartment="cell" initialConcentration="0.576758895" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__FBXO5_APC_FZR1_Ser182u_" name="_cell__FBXO5_APC_FZR1_Ser182u_" compartment="cell" initialConcentration="0.038882221" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__APC_FBXO5_1_FZR1_CDC20_2_Ser355p__FBXO5_APC_1_FZR1_3_Ser182u__FZR1_APC_2_FBXO5_3_nTermu_" name="_cell__APC_FBXO5_1_FZR1_CDC20_2_Ser355p__FBXO5_APC_1_FZR1_3_Ser182u__FZR1_APC_2_FBXO5_3_nTermu_" compartment="cell" initialConcentration="0.003273732" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__APC_FBXO5_FZR1_CDC20_1_Ser355p__FZR1_APC_1_FBXO5_nTermu_" name="_cell__APC_FBXO5_FZR1_CDC20_1_Ser355p__FZR1_APC_1_FBXO5_nTermu_" compartment="cell" initialConcentration="0.03140013" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__FBXO5_APC_FZR1_Ser182p_" name="_cell__FBXO5_APC_FZR1_Ser182p_" compartment="cell" initialConcentration="0.000339715" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__FOXM1_DBD_Thr600u_" name="_cell__FOXM1_DBD_Thr600u_" compartment="cell" initialConcentration="0.010292803" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__FOXM1_DBD_Thr600p_" name="_cell__FOXM1_DBD_Thr600p_" compartment="cell" initialConcentration="0.846869646" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNB_promoter_FOXM1_1__FOXM1_DBD_1_Thr600p_" name="_cell__CCNB_promoter_FOXM1_1__FOXM1_DBD_1_Thr600p_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNB_promoter_FOXM1_" name="_cell__CCNB_promoter_FOXM1_" compartment="cell" initialConcentration="0.0001" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDC20_promoter_FOXM1_" name="_cell__CDC20_promoter_FOXM1_" compartment="cell" initialConcentration="0.0001" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDC20_promoter_FOXM1_1__FOXM1_DBD_1_Thr600p_" name="_cell__CDC20_promoter_FOXM1_1__FOXM1_DBD_1_Thr600p_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__WEE1_Ser123u_" name="_cell__WEE1_Ser123u_" compartment="cell" initialConcentration="0.270170986" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNB_CDK1_Thr14_Tyr15p_" name="_cell__CCNB_CDK1_Thr14_Tyr15p_" compartment="cell" initialConcentration="0.0506526" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__WEE1_Ser123p_" name="_cell__WEE1_Ser123p_" compartment="cell" initialConcentration="3.08300732" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDC25_pSitesp_" name="_cell__CDC25_pSitesp_" compartment="cell" initialConcentration="0.263797157" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CDC25_pSitesu_" name="_cell__CDC25_pSitesu_" compartment="cell" initialConcentration="0.151151385" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__MASTL_Thr198u_" name="_cell__MASTL_Thr198u_" compartment="cell" initialConcentration="0.480833492" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__MASTL_Thr198p_" name="_cell__MASTL_Thr198p_" compartment="cell" initialConcentration="2.464791141" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__ENSA_ARPP19_PPP2R2B_Ser62_Ser67u_" name="_cell__ENSA_ARPP19_PPP2R2B_Ser62_Ser67u_" compartment="cell" initialConcentration="0.788481012" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__ENSA_ARPP19_PPP2R2B_Ser62_Ser67p_" name="_cell__ENSA_ARPP19_PPP2R2B_Ser62_Ser67p_" compartment="cell" initialConcentration="0.134223844" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__ENSA_ARPP19_PPP2R2B_1_Ser62_Ser67p__PPP2R2B_ENSA_ARPP19_1_" name="_cell__ENSA_ARPP19_PPP2R2B_1_Ser62_Ser67p__PPP2R2B_ENSA_ARPP19_1_" compartment="cell" initialConcentration="0.299230995" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNE_promoter_E2F_" name="_cell__CCNE_promoter_E2F_" compartment="cell" initialConcentration="0.0001" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNA_promoter_E2F_" name="_cell__CCNA_promoter_E2F_" compartment="cell" initialConcentration="0.0001" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_promoter_E2F_" name="_cell__E2F_promoter_E2F_" compartment="cell" initialConcentration="0.0001" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__FBXO5_promoter_E2F_" name="_cell__FBXO5_promoter_E2F_" compartment="cell" initialConcentration="0.0001" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__FOXM1_promoter_E2F_" name="_cell__FOXM1_promoter_E2F_" compartment="cell" initialConcentration="0.0001" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" name="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" name="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_" name="_cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_1_RB1_Ser332u__FBXO5_promoter_E2F_1_" name="_cell__E2F_DBD_1_RB1_Ser332u__FBXO5_promoter_E2F_1_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_1_RB1_Ser332u__FOXM1_promoter_E2F_1_" name="_cell__E2F_DBD_1_RB1_Ser332u__FOXM1_promoter_E2F_1_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" name="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" name="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_" name="_cell__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_1_RB1_Ser332p__FBXO5_promoter_E2F_1_" name="_cell__E2F_DBD_1_RB1_Ser332p__FBXO5_promoter_E2F_1_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
<species id="_cell__E2F_DBD_1_RB1_Ser332p__FOXM1_promoter_E2F_1_" name="_cell__E2F_DBD_1_RB1_Ser332p__FOXM1_promoter_E2F_1_" compartment="cell" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false"/>
</listOfSpecies>
<listOfParameters>
<parameter id="kPhRbD" value="0.000648201" constant="true"/>
<parameter id="kPhRbE" value="0.058910671" constant="true"/>
<parameter id="kDpRb" value="0.009738132" constant="true"/>
<parameter id="kPhRb" value="0.031588931" constant="true"/>
<parameter id="kSyCe1" value="2.11784e-05" constant="true"/>
<parameter id="kSyCe2" value="0.789451529" constant="true"/>
<parameter id="kDeCe" value="0.000541561" constant="true"/>
<parameter id="kDiE2fRb" value="4.03325e-05" constant="true"/>
<parameter id="kAsE2fRb" value="0.114480539" constant="true"/>
<parameter id="kSyE2f1" value="1.74125e-06" constant="true"/>
<parameter id="kSyE2f2" value="0.295485145" constant="true"/>
<parameter id="kDeE2f1" value="6.79153e-06" constant="true"/>
<parameter id="kDeE2f2" value="0.000660286" constant="true"/>
<parameter id="kPhE2f" value="0.011885403" constant="true"/>
<parameter id="kDpE2f2" value="0.02680189" constant="true"/>
<parameter id="kSyEmi1" value="4.47293e-05" constant="true"/>
<parameter id="kSyEmi2" value="6.373909639" constant="true"/>
<parameter id="kDeEmi1" value="0.000224008" constant="true"/>
<parameter id="kDeEmi2" value="9.86651e-05" constant="true"/>
<parameter id="kDeEmi3" value="0.001111434" constant="true"/>
<parameter id="kPhEmiA" value="0.000201609" constant="true"/>
<parameter id="kPhEmiB" value="1.49979e-05" constant="true"/>
<parameter id="kDpEmi" value="1.13792e-05" constant="true"/>
<parameter id="kSyCa1" value="1.72474e-05" constant="true"/>
<parameter id="kSyCa2" value="1.235102815" constant="true"/>
<parameter id="kDeCa1" value="3.41161e-07" constant="true"/>
<parameter id="kDeCa2" value="0.01975253" constant="true"/>
<parameter id="kDeCa3" value="0.002050238" constant="true"/>
<parameter id="kDpCdh" value="0.001112314" constant="true"/>
<parameter id="kPhCdhA" value="0.002983994" constant="true"/>
<parameter id="kPhCdhE" value="0.000528755" constant="true"/>
<parameter id="kPhCdhB" value="0.279488223" constant="true"/>
<parameter id="kDiACE" value="0.002511269" constant="true"/>
<parameter id="kAsACE" value="0.057940869" constant="true"/>
<parameter id="kDiACdh" value="8.20995e-05" constant="true"/>
<parameter id="kAsACdh" value="0.029891867" constant="true"/>
<parameter id="kPhCeA" value="0.000709577" constant="true"/>
<parameter id="kPhCeE" value="0.000617137" constant="true"/>
<parameter id="kPhFoxE" value="4.73564e-05" constant="true"/>
<parameter id="kPhFoxA" value="6.94919e-05" constant="true"/>
<parameter id="kPhFoxB" value="0.00166395" constant="true"/>
<parameter id="kDpFox" value="1.08133e-05" constant="true"/>
<parameter id="kSyCb1" value="8.87052e-06" constant="true"/>
<parameter id="kSyCb2" value="2.649274362" constant="true"/>
<parameter id="kDeCb1" value="3.75503e-05" constant="true"/>
<parameter id="kDeCb2" value="8.71152e-05" constant="true"/>
<parameter id="kDeCb3" value="0.000450486" constant="true"/>
<parameter id="kPhEnsa" value="0.000142929" constant="true"/>
<parameter id="kDpEnsa" value="0.000137939" constant="true"/>
<parameter id="kPhGw" value="0.010948504" constant="true"/>
<parameter id="kDpGw1" value="0.009005144" constant="true"/>
<parameter id="kDpGw2" value="0.123020889" constant="true"/>
<parameter id="kWee1" value="9.81246e-06" constant="true"/>
<parameter id="kWee2" value="0.001292832" constant="true"/>
<parameter id="kPhWeeA" value="0.000173818" constant="true"/>
<parameter id="kPhWeeB" value="0.064391371" constant="true"/>
<parameter id="kDpWee" value="0.01383238" constant="true"/>
<parameter id="kCdc25_1" value="0.000374737" constant="true"/>
<parameter id="kCdc25_2" value="0.009924929" constant="true"/>
<parameter id="kDpCdc25" value="0.015243794" constant="true"/>
<parameter id="kDipEB55" value="5.08827e-07" constant="true"/>
<parameter id="kAspEB55" value="3.949756187" constant="true"/>
<parameter id="kSyCdc_1" value="8.50387e-07" constant="true"/>
<parameter id="kSyCdc_2" value="4.872505016" constant="true"/>
<parameter id="kDeCdc_1" value="7.75868e-05" constant="true"/>
<parameter id="kDeCdc_2" value="0.003299429" constant="true"/>
<parameter id="kDipACdc" value="7.84121e-05" constant="true"/>
<parameter id="kAspACdc" value="0.001741454" constant="true"/>
<parameter id="kPhApcA" value="0.002783538" constant="true"/>
<parameter id="kDpApc_1" value="0" constant="true"/>
<parameter id="kDpApc_2" value="2.186710426" constant="true"/>
<parameter id="kSyFox1" value="3.45317e-05" constant="true"/>
<parameter id="kSyFox2" value="0.125750925" constant="true"/>
<parameter id="kDeFox1" value="2.5462e-06" constant="true"/>
<parameter id="kDeFox2" value="0.010864648" constant="true"/>
<parameter id="kAsEPx" value="0.624121833" constant="true"/>
<parameter id="kDiEPx" value="0.004639212" constant="true"/>
<parameter id="kAsFPcb" value="0.061983356" constant="true"/>
<parameter id="kDiFPcb" value="0.042793" constant="true"/>
<parameter id="kAsFPcdc" value="0.81683038" constant="true"/>
<parameter id="kDiFPcdc" value="0.085026565" constant="true"/>
<parameter id="kPhC25B" value="0.012731692" constant="true"/>
<parameter id="kPhCAEE" value="0.001379862" constant="true"/>
<parameter id="kPhCAEA" value="0.040401927" constant="true"/>
<parameter id="kPhCAEB" value="0.014194174" constant="true"/>
<parameter id="kDpE2f1" value="0" constant="true"/>
<parameter id="kPhC25A" value="0" constant="true"/>
<parameter id="_InitialConc1" value="1" constant="true"/>
<parameter id="_InitialConc2" value="0.23224914" constant="true"/>
<parameter id="_InitialConc3" value="0.018479024" constant="true"/>
<parameter id="_InitialConc4" value="3.8081857e-05" constant="true"/>
<parameter id="_InitialConc5" value="0.0070284949" constant="true"/>
<parameter id="_InitialConc6" value="0.0018823629" constant="true"/>
<parameter id="_InitialConc7" value="0.071461332" constant="true"/>
<parameter id="_InitialConc8" value="0.00015053859" constant="true"/>
<parameter id="_InitialConc9" value="0.087642687" constant="true"/>
<parameter id="_InitialConc10" value="0.84074544" constant="true"/>
<parameter id="_InitialConc11" value="0.077191625" constant="true"/>
<parameter id="_InitialConc12" value="4.0287133" constant="true"/>
<parameter id="_InitialConc13" value="0.22995279" constant="true"/>
<parameter id="_InitialConc14" value="0.069890078" constant="true"/>
<parameter id="_InitialConc15" value="0.063091065" constant="true"/>
<parameter id="_InitialConc16" value="0.71354419" constant="true"/>
<parameter id="_InitialConc17" value="0.00057134095" constant="true"/>
<parameter id="_InitialConc18" value="0.16112308" constant="true"/>
<parameter id="_InitialConc19" value="0.10894131" constant="true"/>
<parameter id="_InitialConc20" value="0.00071781614" constant="true"/>
<parameter id="_InitialConc21" value="0.0022125471" constant="true"/>
<parameter id="_InitialConc22" value="0.013607533" constant="true"/>
<parameter id="_InitialConc23" value="1.8804937e-05" constant="true"/>
<parameter id="_InitialConc24" value="0.0055647336" constant="true"/>
<parameter id="_InitialConc25" value="0.00038111617" constant="true"/>
<parameter id="_InitialConc26" value="1.9032592e-07" constant="true"/>
<parameter id="_InitialConc27" value="9.9809674e-05" constant="true"/>
<parameter id="_InitialConc28" value="9.9923815e-05" constant="true"/>
<parameter id="_InitialConc29" value="7.6185347e-08" constant="true"/>
<parameter id="_InitialConc30" value="0.98044163" constant="true"/>
<parameter id="_InitialConc31" value="0.0075129148" constant="true"/>
<parameter id="_InitialConc32" value="0.019558367" constant="true"/>
<parameter id="_InitialConc33" value="0.018438067" constant="true"/>
<parameter id="_InitialConc34" value="0.98156193" constant="true"/>
<parameter id="_InitialConc35" value="0.99752571" constant="true"/>
<parameter id="_InitialConc36" value="0.002474295" constant="true"/>
<parameter id="_InitialConc37" value="0.82686306" constant="true"/>
<parameter id="_InitialConc38" value="0.00032856116" constant="true"/>
<parameter id="_InitialConc39" value="0.17280837" constant="true"/>
<parameter id="_InitialConc40" value="8.4479024e-05" constant="true"/>
<parameter id="_InitialConc41" value="8.4479024e-05" constant="true"/>
<parameter id="_InitialConc42" value="8.4479024e-05" constant="true"/>
<parameter id="_InitialConc43" value="8.4479024e-05" constant="true"/>
<parameter id="_InitialConc44" value="8.4479024e-05" constant="true"/>
<parameter id="_InitialConc45" value="1.5520976e-05" constant="true"/>
<parameter id="_InitialConc46" value="1.5520976e-05" constant="true"/>
<parameter id="_InitialConc47" value="1.5520976e-05" constant="true"/>
<parameter id="_InitialConc48" value="1.5520976e-05" constant="true"/>
<parameter id="_InitialConc49" value="1.5520976e-05" constant="true"/>
<parameter id="_InitialConc50" value="0" constant="true"/>
<parameter id="_InitialConc51" value="0" constant="true"/>
<parameter id="_InitialConc52" value="0" constant="true"/>
<parameter id="_InitialConc53" value="0" constant="true"/>
<parameter id="_InitialConc54" value="0" constant="true"/>
<parameter id="tCCNA" constant="false"/>
<parameter id="tCCNB" constant="false"/>
<parameter id="tCCNE" constant="false"/>
<parameter id="tE2F" constant="false"/>
<parameter id="pRB" constant="false"/>
</listOfParameters>
<listOfRules>
<assignmentRule variable="tCCNA">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<cn> 0 </cn>
<ci> _cell__CCNA </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="tCCNB">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> _cell__CCNB_CDK1_Thr14_Tyr15u_ </ci>
<ci> _cell__CCNB_CDK1_Thr14_Tyr15p_ </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="tCCNE">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<cn> 0 </cn>
<ci> _cell__CCNE </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="tE2F">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci> _cell__E2F_DBD_RB1_Ser332u_ </ci>
<ci> _cell__E2F_DBD_RB1_Ser332p_ </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_ </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_ </ci>
<ci> _cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_ </ci>
<ci> _cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_ </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_ </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332u__FBXO5_promoter_E2F_1_ </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332u__FOXM1_promoter_E2F_1_ </ci>
<ci> _cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_ </ci>
<ci> _cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_ </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_ </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332p__FBXO5_promoter_E2F_1_ </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332p__FOXM1_promoter_E2F_1_ </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="pRB">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<cn> 0 </cn>
<ci> _cell__RB1_E2F_Ser807_Ser811p_ </ci>
</apply>
</math>
</assignmentRule>
</listOfRules>
<listOfReactions>
<reaction id="R1" reversible="false" fast="false">
<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kSyE2f1 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R2" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__FOXM1_DBD_Thr600p_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNB_promoter_FOXM1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNB_promoter_FOXM1_1__FOXM1_DBD_1_Thr600p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kAsFPcb </ci>
<ci> _cell__FOXM1_DBD_Thr600p_ </ci>
<ci> _cell__CCNB_promoter_FOXM1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R3" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNB_promoter_FOXM1_1__FOXM1_DBD_1_Thr600p_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__FOXM1_DBD_Thr600p_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNB_promoter_FOXM1_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDiFPcb </ci>
<ci> _cell__CCNB_promoter_FOXM1_1__FOXM1_DBD_1_Thr600p_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R4" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
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<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kSyE2f2 </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R5" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
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<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kSyE2f2 </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R6" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_RB1_Ser332u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R7" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332p_" stoichiometry="1" constant="true"/>
</listOfReactants>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_RB1_Ser332p_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R8" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R9" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
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<listOfProducts>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R10" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNE_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R11" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNA_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R12" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__E2F_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R13" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332u__FBXO5_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__FBXO5_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332u__FBXO5_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R14" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332u__FOXM1_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__FOXM1_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332u__FOXM1_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R15" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNE_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R16" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNA_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R17" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__E2F_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R18" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332p__FBXO5_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__FBXO5_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332p__FBXO5_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R19" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332p__FOXM1_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__FOXM1_promoter_E2F_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kDeE2f1 </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332p__FOXM1_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R20" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCND" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCND" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhRbD </ci>
<ci> _cell__CCND </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R21" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCND" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCND" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332p_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhRbD </ci>
<ci> _cell__CCND </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R22" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNE" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNE" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhRbE </ci>
<ci> _cell__CCNE </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R23" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNE" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNE" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332p_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhRbE </ci>
<ci> _cell__CCNE </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R24" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhRb </ci>
<ci> _cell__CCNA </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R25" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332p_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhRb </ci>
<ci> _cell__CCNA </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R26" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhRb </ci>
<ci> _cell__CCNB_CDK1_Thr14_Tyr15u_ </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R27" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332p_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__RB1_E2F_Ser807_Ser811p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhRb </ci>
<ci> _cell__CCNB_CDK1_Thr14_Tyr15u_ </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R28" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332p_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__E2F_DBD_RB1_Ser332u_ </ci>
<ci> _cell__CCNA </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R29" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__CCNA </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R30" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__CCNA </ci>
<ci> _cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R31" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__CCNA </ci>
<ci> _cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R32" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332p__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__CCNA </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R33" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332u__FBXO5_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332p__FBXO5_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__CCNA </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332u__FBXO5_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R34" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332u__FOXM1_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNA" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332p__FOXM1_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__CCNA </ci>
<ci> _cell__E2F_DBD_1_RB1_Ser332u__FOXM1_promoter_E2F_1_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R35" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__E2F_DBD_RB1_Ser332p_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__E2F_DBD_RB1_Ser332u_ </ci>
<ci> _cell__CCNB_CDK1_Thr14_Tyr15u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R36" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_RB1_1_Ser332p__RB1_E2F_1_Ser807_Ser811u_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__CCNB_CDK1_Thr14_Tyr15u_ </ci>
<ci> _cell__E2F_DBD_RB1_1_Ser332u__RB1_E2F_1_Ser807_Ser811u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R37" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__CCNB_CDK1_Thr14_Tyr15u_ </ci>
<ci> _cell__CCNE_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R38" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332p_" stoichiometry="1" constant="true"/>
</listOfProducts>
<kineticLaw>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> kPhE2f </ci>
<ci> _cell__CCNB_CDK1_Thr14_Tyr15u_ </ci>
<ci> _cell__CCNA_promoter_E2F_1__E2F_DBD_1_RB1_Ser332u_ </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction id="R39" reversible="false" fast="false">
<listOfReactants>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_" stoichiometry="1" constant="true"/>
<speciesReference species="_cell__E2F_DBD_1_RB1_Ser332u__E2F_promoter_E2F_1_" stoichiometry="1" constant="true"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="_cell__CCNB_CDK1_Thr14_Tyr15u_" stoichiometry="1" constant="true"/>