diff --git a/pyproject.toml b/pyproject.toml
index d8ca304f23..5fa13f97c3 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -49,7 +49,6 @@ dependencies = [
     "rich>=12.0.0",
     "scikit-learn>=0.21.2",
     "scipy",
-    "setuptools<75.7.0",
     "sparse>=0.14.0",
     "tensorboard>=2.0",
     "torch",
diff --git a/tests/data/test_preprocessing.py b/tests/data/test_preprocessing.py
index b9677cf145..434667b0fa 100644
--- a/tests/data/test_preprocessing.py
+++ b/tests/data/test_preprocessing.py
@@ -44,7 +44,7 @@ def test_add_dna_sequence(save_path: str):
         adata,
         seq_len=seq_len,
         genome_name="test_genome",
-        genome_dir=save_path,
+        genome_dir=save_path + "./test_data/",
         install_genome=False,
     )
     assert "dna_sequence" in adata.varm.keys()